What are the features of Nuclear Receptor Screening Services?

Nuclear receptors (NRs) are a class of proteins responsible for thyroid hormones and sensing steroid and certain other molecules. There are 48 genes in the human genome that code for the NRs. As the largest family of eukaryotic transcription factors, NRs control numerous processes involved in development, cell cycle, and important metabolic pathways.

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Answer 1

Answer:

The nuclear receptor superfamily comprises a large group of transcription factors that play a key regulatory role in development and homeostasis of multicellular organisms. A special feature of nuclear receptors is their ability to bind to condensed chromatin templates, which makes them important initiators of gene transcription. Moreover, the ability of nuclear receptors to sequentially recruit a variety of transcription factors and coregulators to target promoters and to orchestrate the whole process of gene transcription confirms their biological significance and stimulates intensive research and a high level of scientific interest in this field. In this review, we summarise current knowledge regarding the structure and function of nuclear receptors as principal regulators of gene expression. Emphasis is given to the molecular mechanisms of nuclear receptor-mediated transcriptional activation and repression including recent progress made in this area.


Related Questions

what are the advantage of the presence of hydrogen in large scale in the sun ?​

Answers

hydrogen is essential to nuclear fusion. hydrogen is the fuel the sun burns. we don't have to burn solar energy, so there's no smoke and pollution

Answer:

Hydrogen fusion reaction is the one which provides so much light and heat (in short, energy) which escapes into space and spread. If Hydrogen on sun ends, It will lose its warmth (and may be soon become a planet, but will surely be a dead star).

Explanation:

Answer from Gauth math

Cellular respiration produces

Answers

The products of cellular respiration are ATP, oxygen and water

other, than photosynthesis which process is Autotrophic.?Give examples too.​

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Answer:

Some rare autotrophs produce food through a process called chemosynthesis, rather than through photosynthesis. ... Instead, they make food using energy from chemical reactions, often combining hydrogen sulfide or methane with oxygen.

Help anyone please????!

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1. Wavelength
2. Compression
3. Rarefractiom
Please mark brainliest

Biology Question

If the frequency of an autosomal dominant allele is 0.6 . Calculate the frequency of recessive phenotype in a population of 6000​

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Answer:

First thing is that word “autonomous” given in the question is actually “ autosomal”.

Now let's start solution:

Frequency of dominant allele “A” is denoted by p.

Here p = 0.6

Frequency of recessive allele “a” is denoted by q.

According to Hardy - Weinberg equilibrium

p + q = 1

Hence q = 1 - p = 1 - 0.6 = 0.4

Now in question what is asked is about frequency of recessive phenotype (aa).

According to Hardy - Wienberg equilibrium frequency of recessive phenotype is q2 (q square).

Frequency of recessive phenotype is = q2 = 0.4 x 0.4 = 0.16

Now Number of recessive phenotype in a population of 10000 is

= frequency of recessive phenotype x total population

= q2 x 10000

= 0.16 x 10000

= 1600

I answer you other question.

I apologize. it's mistakenly

HELP ASAP PLEASE…………….

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A. Cellulose  ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎

Cells can vary enormously in size. The frog egg is 1 mm and the mycobacterium is 100 nm in diameter. Thus the largest cell is _____ times bigger in diameter than the smallest cell.

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Answer:

choices?

Explanation:

please let me know when the choices are up

If you kill someone while driving under the influence, you can

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Answer:

you can go to jail. in most cases you will go to jail

Explanation:

why do you need to know the different body cavities when learning the organization of the human body and its related systems

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Answer:

You can grasp how everything works together to keep you healthy, developing, and strong by studying the many systems that function inside the body. The central nervous system is made up mostly of your brain and spinal cord.

OAmalOHopeO

HELP ASAP NEED HELPPPPP

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Answer:

insects is a write answer.

The term voltage describes the:
-electrical potential difference between two points.
-likelihood that an electrochemical gradient will develop.
-process of molecules moving from an area of high concentration to low
concentration.
-way in which osmosis determines water movement.

Answers

Answer:

electrical potential difference between two points.

Explanation

Voltage refers to the electrical potential difference between two distinct points. It doesn’t describe the way in which osmosis determines water movement (osmotic pressure), nor does it describe the process of molecules moving from an area of high concentration to low concentration (diffusion), or the likelihood that an electrochemical gradient will develop.

The term voltage describes the electrical potential difference between two points. Option A is correct.

Voltage is a measure of the amount of energy that is available to move electrons from one point to another. It is measured in volts (V). The higher the voltage, the more energy is available to move electrons.

The electrical potential difference between two points is created by the difference in the number of electrons at those two points. If there are more electrons at one point than at another, there will be a voltage difference between the two points. This voltage difference will cause electrons to flow from the point with more electrons to the point with fewer electrons. Option A is correct.

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Most of the plant matter in ___ is sphagnum moss.

Answers

Answer:

the answer is peat

Explanation:

i did the test Hope dis help

Answer:

pease

Explanation:

I did some research

what would happen if the diet if a chid provide enough calories but is deficient in poteinsg

very short ​

Answers

Answer:

Serious protein deficiency can cause swelling, fatty liver, skin degeneration, increase the severity of infections and stunt growth in children.

While true deficiency is rare in developed countries, low intake may cause muscle wasting and increase the risk of bone fracture

Hope this helps you :)

a body may have zero velocity even though its speed is 10m/s. give reason.​

Answers

Explanation:

because speed is time rate at which an object is moving along a bath, while velocity is the rate and direction of object's movement .

John wants to test how temperature affects the mass of sugar that can be
dissolved in water. Which of the following factors must be the same between
the control group and the experimental group?
A. The temperature of the water
B. The mass of the sugar
C. The volume of the water
D. The time of day
SUBMIT

Answers

Answer:

c

Explanation:

the volume or temperature ️ of water

2. Calculate the rate of population increase for the whales and the seals from the data in table 2, trial 1. What does this rate represent?
Hint: From the point of zero change on the graph to the highest population achieved is a change in time of 100 months. (Refer to the science skills practice in the lesson for the correct formula for the rate of population change.)

Answers

Answer:

There are no tables but it should be a bell curve. as a population of whales rise the population of seals will decrease, eventually creating a plateau in the whale population. shortly after the plateau in the whale population the whale population will begin to decline ( as food becomes less available) causing the seal population will begin to rise and restabilize. this pattern should continue cyclically creating a wave function on a graph!

Explanation:

What is assimilatory power?

Answers

A military, also known collectively as armed forces, is a heavily armed, highly organized force primarily intended for warfare. It is typically officially authorized and maintained by a sovereign state, with its members identifiable by their distinct military uniform. 

Find out the chemical names and formula e for the following common house hold substances - a) common salt b) baking soda c) washing soda d.) vinegar ​

Answers

Salt: Sodium Chloride, NaCl
Baking Soda: Sodium hydrogen carbonate or Sodium bicarbonate, NaHCO3
Washing Soda: sodium carbonate decahydrate, Na2CO3 10H2O
Vinegar: Acetic acid, CH3COOH

The Calvin Cycle can best be described as which type of reaction?

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Answer:

In plants, carbon dioxide (CO2) enters the chloroplast through the stomata and diffuses into the stroma of the chloroplast—the site of the Calvin cycle reactions where sugar is synthesized. ... This type of reaction is called a reduction reaction, because it involves the gain of electrons.

how are traits which are not beneficial to a living organism removed from its gene pool

Answers

Answer:

recessive traits is the answer

Organisms who carry those traits are less likely to be chosen as a mate, slowly reducing that gene from the species

when would a recessive trait be seen in an organism? A. When there is one dominant and one recessive gene for the trait present in the offspring. B. When there are two dominant genes for the trait present in the offspirng. C. When there are two recessive genes for the trait present in the offspring D. Never

Answers

A when there’s one dominant and one recessive gene for the trait present in the offspring

a special effects artist mixes two different liquids in a bowl. both liquids are white. when she heats the bowl, a new compound forms. will the new compound be a white liquid?

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Answer:

if a special effects artist mixes two different liquids in a bowl and they both are too white !

after heats those liquids

its forms curd like substance

its either will be white, its can increase its colour as darkish white or lightly yellowishblack

when she heats the bowl, a new compound forms and it will be white before heating and after heating it may be white or other dark color.

What are the properties of a compound ?

A compound composed up of two or more elements which are chemically combined with a fixed proportion by their mass.

For example, Water, Sodium Chloride,  Ammonium Chloride etc.

They have fixed melting and  boiling points.

Formation of compound is a change in chemical reaction and the components of compound are mixed in a fixed proportion.

Two major types of compounds are covalent and ionic compounds.

Covalent compounds refers to formation of covalent bond among two nonmetals, like water or methane. These molecules are neutral and weak.

When metal react with non metal it form Ionic compounds, are held together by opposite charges, so the bond is stronger than covalent compound.

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I need help! Pls help!!!

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(iii) Enzymes P, Q and R (choose any one)

P - pepsin / protease

Q - amylase / carbohydrase

R - lipase / trypsin / protease / amylase

(c) There are many ways in which different types of enzymes are using in preparing baby foods such as the amylase breaks down the starch and the starch breaks down to maltose or glucose. The protease breaks down protein and the protein breaks down into amino acids. The lipase breaks down fats and then the fats break down to gylcerol.

Hope it's help you.If it is right

The Cell-mediated response is a chain reaction of antigens and Interleukins that results in:
A. The swelling of fluid and clotting elements to a damaged area.
B. The differentiation of helper T cells into cytotoxic T cells to destroy pathogens.
C. The production of macrophages to use phagocytosis on pathogens.
D. The differentiation of effector B cells into plasma cells to make antibodies.

Answers

The Cell-mediated response results in the production of macrophages to use phagocytosis on pathogens. The correct option is C.

Cell mediated immune response occurs when an invading antigen causes the release of cytokines (Interleukins), differentiation of T cells and production of macrophages.

Macrophages are produced through the differenciation of monocytes. They are further activated during an infection through the macrophage-activating cytokine (Interleukins).

Phagocytosis is the process used by immune cells such as macrophages  which involves ingesting and eliminating pathogenic microorganisms.

Cell-mediated response dosent result to differenciation of helper T cells into cytotoxic T cells rather it leads to the activation of cytotoxic T cells. Therefore B is wrong.

Cell-mediated response dosen't lead to the production of antibodies therefore option D is wrong.

Learn more here:

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Which of the following are parts of the cardiovascular system? |a) Blood O b) Heart c) Lungs O d) Blood vessels

Answers

Which of the following are parts of the cardiovascular system?

a) Blood

b) Heart

d) Blood vessels

Choose: a); b); d)

Answer:

[tex]except(c \: ) \\ al l \: are \: ur \: option \\ thank \: you[/tex]

What are the main structural supports for the vertebrae

Answers

Answer:

Intervertebral Discs

Explanation:

Between each vertebral body is a cushion; the intervertebral disc. Discs absorb stresses the body incurs during movement and prevents vertebrae from grinding against one another. The intervertebral discs are the largest structures in the body without a vascular supply

Answer:

The dorsal hollow nerve cord

Explanation:

The dorsal hollow nerve cord develops into the central nervous system;the brain and spine


Devise an experiment to test the effect of pH on the activity of biological washing powder

Answers

Answer:

boil a water on a container deep your face inside it and you know the temperature ️ of water

The catalyst which hasten the rate of a metabolic conversion are
1) lipid
2) polysaccharide
3) protein
4) fatty acid​

Answers

[tex]\huge\blue{ANSWER}:—[/tex]

Proteins is the correct option

hope it helps you!

Explanation:

3) protein

The catalyst which hasten the rate of a metabolic conversion are proteins

What is meant by a neutral symbiotic
relationship?
A. At least one organism is harmed.
B. At least one organism gains.
C. At least one organism is unaffected.

Answers

I think answer is option B.

what challenges do scientists face when classifying a new fossil?

Answers

Answer:

You have to clean the fossils and figure out how old they are and what kind of fossils they are.

Explanation:

Answer:

They are often broken and not complete

Explanation:

Due to aging they are often broken and not complete which could make it difficult if you do not have the entire thing.   It's also difficult because there are slight differences between organisms.

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