The synthesis of cholesterol is a process that involves over 30 different steps. Which step is the rate-determining step of cholesterol synthesis?1) The conversion of mevalonic acid to isopentenyl pyrophosphate2) The conversion of squalene into squalene 2,3-epoxide by squalene monooxygenase.3) The condensation of two acetyl-CoA molecules to acetoacetyl-CoA by thiolase.4) The conversion of HMG-CoA to mevalonate by HMG-CoA reductase.

Answers

Answer 1

Answer:

The conversion of HMG-CoA to mevalonate by HMG-CoA reductase

Explanation:

Cholesterol is one of the steroids found in the cell membranes of the eukaryotes, mainly in animal cells. It has a long fatty acid chain that is derived from the acetyl CoA. Biosynthesis of cholesterol includes four steps. The first step is the condensation reaction that forms mevalonate from the three acetate residues. The mevalonate is a six-carbon substance. It is followed by the formation of the isoprene units from the mevalonate.  

The first step of the cholesterol biosynthesis that forms mevalonate from the acetate is a rate-limiting step. First, two molecules of acetyl CoA react to form acetoacetyl-CoA. It is followed by the joining of the third acetyl CoA to form HMG-CoA, a compound with six carbon atoms. The synthesis of the HMG-CoA from acetoacetyl-CoA is catalyzed by the HMG-CoA synthase. The HMG-CoA is then reduced into mevalonate, a reaction catalyzed by HMG-CoA reductase. Here, two molecules of NADPH serve as electron donors.  

The pathway of cholesterol biosynthesis is regulated by the concentration of the cholesterol present in the cell and the pancreatic hormones. Accordingly, the expression of the gene encoding HMG-CoA reductase is regulated to determine the rate of the pathway, making this step a rate-determining step.

HMG-CoA reductase is present in two alternative forms: the phosphorylated form is the inactive form while the dephosphorylated form is the active form of the enzyme.

When the cholesterol levels are high, the hormone glucagon triggers the inactive of the enzyme by its phosphorylation. This covalent modification is reversible and the enzyme is dephosphorylated under the influence of hormone insulin when the intracellular cholesterol levels are low. In this way, covalent modification of the enzyme HMG-CoA reductase regulates the cholesterol biosynthesis.  


Related Questions

Which of the following carries out photosynthesis?
1. Bacteria
2 . Animals and fungi
3. Plants and some bacteria
4 . All living organisms

Answers

Answer:

3.plant and bacteria


The deep water canyons that form in the ocean floor where two plates pull apart are
called?
ridges.
hot spots.
trenches.
faults.

Answers

Answer:

trenches

Explanation:

hope it helps !

If a net force of 24 Newton’s is applied on an object of mass 6 kilograms, what will be the acceleration of the object

Answers

Answer: 4 m/s

Explanation:

i got it right

The acceleration of the object is 4 m/s²

From Newton's second law of motion which states that, " the force acting on an object is equal to the to mass of of that object times its acceleration"

That is,

F = ma

Where

F is the force

m is the mass

and a is the acceleration

From the formula

F = ma

We can write that

[tex]a = \frac{F}{m}[/tex]

From the given information

F = 24 N

m = 6 kg

Putting the parameters into the formula,

[tex]a = \frac{F}{m}[/tex]

We get

[tex]a = \frac{24}{6}[/tex]

∴ a = 4 m/s²

Hence, the acceleration of the object is 4 m/s²

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Where are proteins made in the cell?

nucleus
ribosomes
cytoplasm
cell membrane

Answers

Answer:

Ribosomes

Explanation:

The nucleolus within the nucleus is the site for ribosome assembly. Ribosomes are found in the cytoplasm or are attached to the cytoplasmic side of the plasma membrane or endoplasmic reticulum. They perform protein synthesis. Mitochondria perform cellular respiration and produce ATP.

Hello friens is a banana a vegetable

Answers

Answer:

I don't even know

Probably not because when you search up if it is a fruit or vegetable it shows up fruit

i would say no banana is not a vegetable

because it has seeds

Click the picture to make it bigger need ASAP :D

Answers

my name is jeff my name is jeff

Answer:

C

Explanation:

Water is properly what??

Answers

I don’t understand-
Water is liquid??? But aye I have a small brain
Regulates body temperature
Moistens tissues in the eyes, nose and mouth
Protects body organs and tissues
Carries nutrients and oxygen to cells
Lubricates joints
Lessens burden the on kidneys and liver by flushing out waste products
Helps dissolve minerals and nutrients to make them accessible to your body

Which number would be a best part of a life of a cycle
A. A life that cycle and it goes round round until it end
B. A movement of nerves system going up down moving like a cycle
C.A cycle that ages and never dies but goes and have movement of a cycle and it up down and reach to fowl
D.All of the above

Answers

Answer:

all of the above

Explanation:

Which number would be a best part of a life of a cycle

A. A life that cycle and it goes round round until it end

B. A movement of nerves system going up down moving like a cycle

C.A cycle that ages and never dies but goes and have movement of a cycle and it up down and reach to fowl

is all right mark as brainliset please

Answer:

A

Explanation:

becouse life goes round take example of human being first the birth and then his death

how does the amazonian lily fight for light

Answers

Answer:

a. Bamboo

b. Rattan

c. Amazonian lily

Explanation:

B
Hfhfhjfhfjrjtjrnfnfn

A single cell undergoes mitosis every five minutes. How many cells will result from this cell in 20 minutes?
a.
4
c.
16
b.
8
d.
20

Answers

The answer to this question would be 4 cells because since one cell goes through mitosis every five minutes, 5x4 is 20. Meaning that it would be 4 cells

Answer:

it suppose to be c

Explanation:

because i took the test but i thought  it was a but it suppose to be c

22. These three images represent the particle arrangement in ice, water, and steam.
Which of the following correctly identifies the states of matter?

Answers

Answer:

A

Explanation: Solid's particles are compacted together so C would be ice, water is not is compact as ice is so water would be B, and lasty gas is well gas so it moves around freely which means the gases particles aren't as compact as water and ice, so gas would be A

A student walking by a classroom heard a teacher talking about the accelerated warming of the Earth as a result of additional greenhouse gases being released into the atmosphere through the burning of fossil fuels. Which of the following terms describes what the teacher was talking about?
A)
global warming
B)
climate change
C)
weather
D)
space science
E)
greenhouse farming

Answers

I think it’s C) weather

Answer:

a) global warming

Which of the following represents a way that animals in a zoo are influenced by their environment?
a. increased natural instincts
b. decreased aggression
C. unnatural behavior
d. increased appetite

Answers

The unnatural behavior of animals is a way that animals in a zoo are influenced by their environment.

How are animals influenced in a zoo?

Animals kept in a zoo are influenced by the environment they inhabit.

The environment of the zoo is different from that of the wild. This means that animals will behave differently than they do in their natural habitat.

One of the ways the environment of a zoo influences animals is that they behave in an unnatural way.

Learn more about zoos at: https://brainly.com/question/2271610

The unnatural behavior of animals is a way that animals in a zoo are influenced by their environment.

What is Environment?

All living and non-living objects that occur naturally, or in this example, without the use of artificial means, are included in the natural environment or natural world. The phrase is most frequently used with reference to Earth or certain regions of it.

Complete ecological units, including all flora, microbes, soil, rocks, the atmosphere, and natural phenomena that take place within their bounds and their nature, that function as natural systems without significant civilized human interference.

Natural resources that are available to everyone as well as universal physical phenomena without distinct borders including energy, radiation, electric charge, and magnetism.

Therefore, The unnatural behavior of animals is a way that animals in a zoo are influenced by their environment.

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A plant grows toward the sun shining in a window =

What is this called?

Answers

Answer:

phototropism.

Even mature plants bend toward the strongest light. They do this by elongating the cells of the stem on the side that is farthest from the light. This type of light-oriented growth is called phototropism.

The answer is phototropism

How does Cellular respiration show conservation of matter


Will give a brainless to someone who answers it correctly

Answers

Answer:

The amount of carbon-dioxide atoms released by respiration are exactly equal to the atoms of these materials contained in the oxygen and carbon converted.

Explanation:

When heavier more dense oceanic crust is pushed under less dense continental
crust, what time of landforms does this create?
trenches
volcanoes
mountains
rifts

Answers

Answer:

trench

Explanation:

Satellite technology has allowed us to monitor areas that were once so remote that they had no way of monitoring them review the statements and choose the one that best describes how we can use this technology to benefit the environment

A. Satellites can help world leaders monitor the rate of clearing in the rainforest this can help the direct conservation efforts and notify local officials of a legal clearing activities
B Satellites can help us monitor and track storms tracking the storms help us predict the weather
C. Satellites can help us monitor movement of ships in the ocean this can help us know if a ship is going to be late to port.
D. Satellites can help us monitor the movements of people this can help us by improving national security

Answers

Answer:

The answerer above is incorrect the correct answer is in fact A!

Explanation:

On my final exam for FLVS I got this answer incorrect after marking B, the question is shown below

-------------------------------------------------------------------------------------------------------------

Question 39 (Worth 2 points)

Satellite technology has allowed us to monitor areas that were once so remote that we had no way of monitoring them. Review the statements and choose the one that best describes how we can use this technology to benefit the environment.

Satellites can help world leaders monitor the rate of clearing in the rainforests. This can help them direct conservation efforts and notify local officials of illegal clearing activities.

Satellites can help us monitor and track storms. Tracking the storms helps us predict the weather. This is my answer, by the way, that's why it's marked, be aware this is the incorrect one!

Satellites can help us monitor movement of ships in the ocean. This can help us know if a ship is going to be late to port.

Satellites can help us monitor the movement of people. This can help us by improving national security.

Points earned on this question: 0

--------------------------------------------------------------------------------------------------------------

If you pay attention to the question you may notice that it says "To benefit the environment"

Tracking weather is not helping the environment, it helps us, such as C and D

But A is about using the technology to save our Rainforests Therefore the one who answered above is incorrect meaning the true answer is A!

Answer:

A

Explanation:

A. Satellites can help world leaders monitor the rate of clearing in the rainforest this can help the direct conservation efforts and notify local officials of a legal clearing activities 

Which of the following statements indicate why the cell theory is a theory instead of a law?

Answers

Answer:

Cell theory is theory instead of law because cell theory doesn't have enough support to become a law

Compare and contrast physical and chemical properties of matter.

Answers

Answer:

Intensive properties, such as density and color, do not depend on the amount of the substance present. Physical properties can be measured without changing a substance's chemical identity. Chemical properties can be measured only by changing a substance's chemical identity.

Explanation:

got it from google hope it helps

what basic chemical do we break apart during cellular respiration

fats

glucose

water

or

amino acids

Answers

Answer:

glucose

Explanation:

During cellular respiration, living cells break apart the glucose molecules.

In this process, energy is being released.

It's the process of burning because the breaking apart of glucose releases the energy slowly and uses it for biochemical processes. Glucose and oxygen react and form carbon dioxide and water, and in this way, they release energy.

Fossil fuels are used in many ways. Using the gizmo, describe the main use for each fuel

Answers

Answer:

Fossil fuels are used to generate energy and are responsible for global warming.

Explanation:

Fossil fuel is a residue that is formed by reaming the plants and animals that have been buried inside the earth for thousands of years. Fossil fuels are a conventional form of energy and cannot be renewed. These energy sources are used by man for burning, lightning, etc. Fossil fuels are a cheap source of power and energy supply there are many types as coal, oil or petroleum, uranium, and natural gas. Use din coal plants, use in vehicles, electricity, and heating.

Atom A and Atom B have the same number of protons and neutrons, but they do not have the same number of electrons. Which statement describes the atoms? The atoms have the same chemical symbol. The atoms have the same charge. The atoms have different atomic numbers. The atoms have different atomic masses.

Answers

Answer: C- The atoms have different atomic numbers

Explanation:

Answer:

The atom have different atomic numbers.

Explanation:

Yhu welcome for the answer ill help any time

Marking PEOPLE AS BRAINLIST ⚠️

What would happen if something interfered with cellular divisionn

Answers

Answer:

If they do not align correctly, they cannot move individually to opposite poles in the later phases of mitosis, and the result will be one cell with extra chromosomes and a daughter cell with missing chromosomes. These mutations can lead to harmful results such as cell death, organic disease or cancer.

Explanation:


Florida's coastline is only 2-3 feet above sea level which makes it very
vulnerable to:
extreme heat
O drought
storm surges
wildfire

Answers

Answer:

vulnerable to extreme heat

Explanation:

I just know it

Florida's coastline is only 2-3 feet above sea level which makes it very vulnerable to extreme heat. Thus, the correct option for this question is A.

What is Vulnerability?

Vulnerability may be defined as a circumstance that certainly belongs to a group of events that is either oppressed or more susceptible to harm for numerous living species and their properties. The coastline of Florida is only 2-3 feet above sea level.

That makes it a huge vulnerability to extreme heat. This is because the sea captures the emitting radiations directly from sunlight and thereof, increases the average temperature of the sea as well as the region that are present near it.

Therefore, Florida's coastline is only 2-3 feet above sea level which makes it very vulnerable to extreme heat. Thus, the correct option for this question is A.

To learn more about Vulnerability, refer to the link:

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How do plants and fish impact the pH of the lake?

Answers

Answer:

In fact, dead plants can have a strong effect on pH. In aquariums, dead plants can rot, releasing ammonia and other nitrogen compounds into the water, thus reducing the pH. Although ammonia is toxic to aquarium fish, a decreasing pH will actually make it marginally less toxic

Explanation:

[30 POINTS] DONT USE GOOGLE, ANSWER NOW PLEASE!!

What is the advantage for small monocellular organisms to reproduce asexually?

Answers

Answer:

hope this helps

Explanation:

Some plants and unicellular organisms reproduce asexually. Most mammals and fish use sexual reproduction. Some organisms like corals and komodo dragons can reproduce either sexually or asexually.

A tree falls and is covered in mud over time the wood rite away and minerals seep into were the wood once was the tree now seems like it is made of rock

Answers

Answer:

Petrified

Explanation:

petrified fossils formed when trees that died millions of years ago fell and became covered in mud and sand. Minerals seeped into the wood of the trees. Over time, the wood rotted away and the minerals took its place.

If a normal plant were put in a dark room , why would the Calvin cycle eventually stop

B: the plant would be unable to take in a carbon dioxide

C: the product of the light reaction are needed for the Calvin cycle to occur

D: the Calvin cycle would never stop, unless you stop watering the plant

Answers

Answer:

C

Explanation:

Just took the test good luck

If the normal plant were kept in a dark room then Calvin cycle eventually stop as the product of the light reaction are needed for the Calvin cycle to occur. The correct option is C.

What is Calvin cycle?

Carbon atoms from CO2 used to build three-carbon sugars in the Calvin cycle. This process is powered by and dependent on the light reactions' ATP and NADPH.

If the normal plant were kept in a dark room then Calvin cycle eventually stop as the product of the light reaction are needed for the Calvin cycle to occur.

Thus, the correct option is C.

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select the answer choice with increased levels of organization​

Answers

Answer:

The answer is S.

All living organisms break down sugar to obtain energy using cellular respiration, Which of the following chemical reactions represents the process of aerobic cellular respiration

Answers

Answer:

The chemical reaction that represents the process of aerobic cell respiration is oxygen + glucose → water + carbon dioxide + energy

Explanation:

Cell respiration occurs in the mitochondria of eukaryotic cells and consists of a series of chemical reactions in which energy in the form of ATP molecules is obtained from a glucose molecule in the presence of oxygen.

Glucose is the main energetic substrate to be able to synthesize energy in the form of ATP, through oxidative phosphorylation. At the end of the process ATP is obtained as products, and as waste compounds water and carbon dioxide, which can be schematized in the following chemical reaction:

                           C₆H₁₂O₆  +  6O₂ →  6H₂O  +  6CO₂ + ATP ↑

               Glucose + Oxygen → Water + Carbon dioxide + Energy ↑

This reaction summarizes what happens in aerobic cellular breathing, which is necessary to synthesize energy for cellular functions.

The other reactions:

oxygen + water glucose + lactose glucose + lactose oxygen + water water + carbon dioxide + energy oxygen + glucose

do not represent the components or the order of the reactions that occur in aerobic cell respiration

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