Suppose a researcher introduces a mutation into the glucosidase domain of the mammalian glycogen debranching enzyme. The mutation inhibits the activity of the glucosidase but does not affect the other functions of the enzyme. The researcher then introduces the mutated enzyme into mammalian cells that do not express wild type glycogen debranching enzyme. Predict the effect of the mutation on glycogen metabolism.

Answers

Answer 1

Answer:

cells will have glycogen molecules with branches of a single glucose residue

Explanation:

Glycogen debranching enzymes are proteins that catalyze the removal of branching from glycogen, which is a multibranched polysaccharide composed of glucose units and serves as a form of energy storage. These enzymes have two catalytic activities on a single polypeptide chain: glucosyltransferase and glucosidase activities, which are both required for glycogen breakdown. Glycogen degradation requires both glycogen phosphorylase and glycogen debranching enzymes. First, a glycogen phosphorylase acts to digest a glycogen branch down to four glucose residues. Subsequently, the debranching enzyme through its glucosyltransferase activity acts to transfer three glucose residues to a nearby branch of the glycogen chain. Finally, through its glucosidase activity, the debranching enzyme cleaves the remaining α-1,6 linkage in order to release free glucose.


Related Questions

The process by which dissolved gases are exchanged between the blood and interstitial fluids is Select one: a. cellular respiration. b. diffusion. c. external respiration. d. breathing. e. pulmonary ventilation.

Answers

Answer:

b. diffusion.

Explanation:

Diffusion can be defined as the movement of gas molecules from a region of high concentration to a region of lower concentration until an equilibrium is attained or reached. This mixing of gas molecules in the liquid or gaseous state is due to their kinetic energy of random motion i.e without requiring bulk motion.

This ultimately implies that, diffusion is a phenomenon through which gas molecules in either a gaseous or liquid state spread out in response to a concentration gradient, which is simply the difference in concentration of the gases across a space.

During diffusion, molecules move from areas of high concentration to areas of low concentration.

In this context, the process by which dissolved gases are exchanged between the blood and interstitial fluids is referred to as diffusion.

On a related note, this process is also referred to as internal respiration because it involves the exchange of oxygen gas and carbon (II) oxide gas between tissue cell and capillaries.

ronmental Science
17.1.2 Quiz: Characteristics of Populations
Question 1 of 10
What do members of a population have in common? Select all that apply.
A. They live in the same area.
OB. They have the same density.
C. They are the same species.
D. They are the same size.
O E. They live at the same time.

Answers

Answer:

A,C,D

Explanation:

A- Makes Sense because if you were a member of a population then the other members live in the same area as you.

B- Doesnt make sense because even though you live in the same population as someone, it doesnt mean you'd have the same density.

C- Makes sense because the definition of population is "a group of individuals of the same species living and interbreeding within a given area.

D- Doesnt make sense everyone is different size.

E- Makes sense in order to be considered a member of a population you have to be living

In April 1990, the El Paso County (Colorado) Health Department recognized an outbreak of drug-resistant gonorrhea in Colorado Springs. 56 cases of penicillin- resistant Neisseria gonorrheae occurred from December 1989 through March 1991. To gather information about the outbreak, 410 persons related through a densely connected set of social or sexual associations were interviewed. What can public health workers tell individuals in this network to stop the spread of Gonorrhea in this population?
a) Preventive treatment with penicillin will prevent Gonorrhea infection in individuals not already infected.
b) Only individuals with symptoms should seek medical screening since all cases of Gonorrhea are associated with symptoms.
c) Condoms will not prevent the spread of Gonorrhea. Gonorrhea can spread from an infected mother to a fetus.
d) Gonorrhea is more prevalent in individuals 24 years and older.

Answers

Answer:

c) Condoms will not prevent the spread of Gonorrhea. Gonorrhea can spread from an infected mother to a fetus.

Explanation:

To prevent the spread of infection, it is important that healthcare professionals inform people about ways to protect themselves against infection. In addition, it is important that health professionals inform the dangers that this infection can cause, such as symptoms and rapid transmission, which can even happen from mother to fetus. On how to protect themselves, health professionals can say that the use of condoms is the most efficient form of protection.

silicon and _______ stay in the the outer cells pls tell me fast​

Answers

Answer:

It could be halogens for example things like fluorine

Many anti-evolutionists believe that since science doesn't have answers for all questions; scientific conclusions are not necessarily correct. This attitude reflects a failure to understand the nature of science. What is the general nature of scientific thinking? In what way is science "self correcting"?

Answers

Answer:

Explanation:

they have proven it.

The nature of science and general nature of scientific thinking is discussed as follows:

Scientific thinking:

A proper and orderly method of investigation on the specific idea to formulate testable hypotheses is called scientific thinking. To test these hypotheses, experiments are required.

The general nature of scientific thinking:

a systematic method of investigation. It involves recognition of different variables, making a hypothesis, and testing and validation of the hypothesis. any scientific theory or statement is not certain and valid forever in nature as new evidence can be contradictory.

Self-correcting:

Hypotheses are tested by a specific research design. Every test found new unknown variables that will influence the original hypotheses. It is the self-corrective feature of science.

Learn more about the scientific method:

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A scientist places 25 mg of bacteria in a culture for an experiment and he finds that the mass of the bacteria triples every day. The mass of the bacteria in the culture on any given day is what percent of the mass of bacteria in the culture exactly one day prior

Answers

Answer:

300%

Explanation:

The mass of the bacterial culture is triples everyday, meaning that after one day the culture will have 300% of the mass as the culture one day prior.

Which of the following statements is true about interacting with people from different cultures? O a) Most people within a culture think and act the same. O b) It's important to treat people from different cultures as individuals. Oc) Some cultures are better than other cultures. Generalizations and stereotypes don't impact people's perceptions of cultures.

Answers

Answer:

I hope it helps you

I think b is the answer

g In order to stimulate the renin-angtiotensin-aldosterone system (RAAS), _______________ cells in the kidney detect _______________blood pressure which causes ________________ to be released from the juxtaglomerular cells.

Answers

Answer:

Macula densa cells, lower and renin.

Explanation:

Macula densa cells in the kidney detect lowers blood pressure which causes renin to be released from the juxtaglomerular cells which is  an enzyme. The arterial cells observe the drop in blood pressure, and the decrease in Na concentration is transfer to them by the macula densa cells. The juxtaglomerular cells then release an enzyme called renin. Renin converts angiotensinogen which is a peptide, or amino acid derivative into angiotensin-1.

why do sun spots appear darker than their surroundings

Answers

Answer:

they are comer than their surroundings.

Sunspots are cooler because their magnetic fields inhibit the replenishing of heat from convective flows (due to the interaction between plasma and magnetic fields). This allows them to cool radiatively. The rest of the solar surface is constantly being replenished by convective cells that reheat it.

Answer:

because they are significantly cooler than the rest of the Sun's surface Despite their gloomy appearance, they are nonetheless extremely hot. A sunspot would shine brightly if it were alone in space.

OAmalOHopeO

1. Describe the purpose of mitosis.
2. Describe what is happening in each stage and what each stage looks like:
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

Answers

Answer:

1) The purpose of mitosis is growth and repair of cells

Explanation:

Prophase:

-DNA condenses (supercoiled, chromatids are visible under light microscope);

-Nuclear membrane begins to disintegrate (by the end of prophase  it is completely gone)

-Centrioles move to opposite ends of the cell

-Splinde fibers start to form from the centrioles and grow

Metaphase:

-Spindle fibers, departing from both poles, are attached to each centromere, on opposite sides

-The spindle fibers pull the chromosomes back and forth until they align in a plane along the equator of the cell, which is called the equatorial plane

Anaphase:

-The spindle fibers shorten

-The centromeres of sister chromatids split

-Chromatids move apart, pulled by the spindle fibers

-Chromatids become chromosomes

-Half of the chromosomes move to one cell pole, half to the other

Telophase:

-The chromosomes reach the cell pole

-Nuclear membrane reforms

-Spindle fibers break down and disappear

-The chromosomes begin to uncoil, which makes them diffuse and less compact

Cytokinesis:

-The cell membrane pinches inward until the cell divides in two;

-There are two daughter cells with the same structures and number of chromosomes as the parent cell

-Chromosomes decondense

Question 4 of 10
Erin is studying the rate at which bananas turn brown as part of her science
fair project. Her teacher asked her to include a scientific question in the
presentation. Which of the following is a reasonable scientific question for
Erin's project?
A. Do bananas prefer the temperature inside the refrigerator or on the
countertop?
B. Should students be required to do science fair projects?
C. What hypothesis is likely to lead to a winning science fair project?
D. How does the air temperature affect the rate at which a banana
turns brown?

Answers

Answer:

D. How does the air temperature affect the rate at which a banana

turns brown?

If a physicist performs an experiment, who would likely try to replicate it?

The physicist himself
Other physicists
The family of the physicist
No one, because an experiment can never be replicated

Answers

I think the answer is the second one.

Sophia
Which of the following represents the correct flow of information during
homeostasis?
Home
a.) Integrator - Sensor - Effector
O b.) Sensor - Integrator - Effector
Hi
WHAT'S
oc.) Sensor - Effector - Integrator
Welcome to
allows your
o d.) Effector + Integrator + Sensor
1. Homeo
2 Sensors

Answers

Answer:

b.) Sensor - Integrator - Effector

Explanation:

During homeostasis, our body sense change that occur in the external environment through sensors. These sensors sends the information to integrator or the control center where the information is analyzed. After analysis, the instructions are send to the effectors to take action against the change which is occur in the external environment of our body so the correct order of homeostasis is Sensor - Integrator - Effector.

Which label should Megan add to complete her chart?
O Maple, 19%
O Maple, 29%
O Maple, 39%
O Maple, 49%

Answers

Answer:

Megan should add Maple, 39%

OAmalOHopeO:

Answer: The answer is C

Explanation:

just add them up unlit you get a total of 100 percent. But 39 is the correct answer 7+12+15+27+39=100

Which structure transports urine to the bladder by peristaltic action?

Answers

Answer:

The muscular layer of the ureter consists of longitudinal and circular smooth muscles that create the peristaltic contractions to move the urine into the bladder without the aid of gravity.

Answer:

The ureter

Explanation:

The ureter is a long thin tubular structure 10-12 inches long which carries urine produced in the kidney to the bladder. The urine is transported by a process called peristalsis. The ureter actively propels urine from the kidney down into the bladder.

Which of the following statements about eutrophication is TRUE?
a) Eutrophic bodies of water are characterized by clear water that is relatively free of algae. •
b) Climate change is expected to worsen eutrophication because many phytoplankton grow better in warm water
c) Eutrophication is typically driven by natural processes like rock weathering and nitrogen fixation
d) Eutrophication can harm fish and other aquatic species but does not cause health problems for humans

Answers

Answer:

c) eutrophication is typically driven by natural processes like rock weathering and nitrogen fixation.eutrophication happens when too much nitrogen enriches the soil, causing excess growth of plants and algea.

I hope this helps

When nitrogen from fertilizers seeps into soil, it frequently fosters weed growth rather than the development of native plants. The excess of nutrients caused by nitrogen washing into streams is known as eutrophication. Thus, option C is correct.

What best define about eutrophication?

A surplus of nutrients in water, primarily nitrogen and phosphorus, causes a process called eutrophication. By consuming the nutrients, algae flourish, proliferate, and tint the water green.

Algae blooms can have an unpleasant odor, restrict sunlight, and in some circumstances even produce toxins.

The process of eutrophication occurs when a body of water receives an excessive amount of nutrients, which increases the growth of algae and macrophytes. It causes water bodies' dissolved oxygen levels to drop and their water quality to deteriorate.

Therefore, Eutrophication is typically driven by natural processes like rock weathering and nitrogen fixation.

Learn more about eutrophication here:

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New world monkeys have:______.
a. None of the above
b. have short legs and no tails to help them balance on top of the branches where they walk
c. have prehensile tails to aid in their 3-D movement through the trees
d. have broad and flat bodies with the scapula on the back of the ribcage, allowing a greater range of motion in the shoulder and for them to hold their arms above their heads.

Answers

Answer:

d num have broad and flat bodies

Answer:

C. have prehensile tails to aid in their 3-D movement through the trees

Explanation:Monkeys need tails to balance themselves when walking and jumping from tree to tree

QUESTION 6
Which one of the following substances is not a product of aerobic respiration?
A.
ATP
B.
Water
C.
Alcohol
D. Carbon dioxide​

Answers

Answer:

C. alcahol

Explanation:

aerobic respiration equation

glucose+ oxygen -> carbob dioxide gas + water + energy

Answer:C

Explanation:

characteristics of invertebrates​

Answers

Answer:

they don't have back bone.

Heart is to pump blood as stomach is to​

Answers

Answer:

hcl is present to clean other harmful acids

Classify amoeba to species level

Answers

Domain: Eukaryota
Kingdom: Amoebozoa
Phylum: Tubulinea
Order: Tubulinida
Family: Amoebidae
Genus: Amoeba
Species: Proteus, Animalcule, Dubia, Animulecule, etc


Please mark as brainliest if it’s rigjt thx

If the average length of a woman's ovarian cycle is 30 days, the average length of her uterine cycles is most likely ____ days.

a. 7
b. 30
c. 21
d. 15
e. 10

Answers

It most likely 30 days
Most likely 21 to 35 days, so I would choose 21 here.

In _______, with the help of Rosalind Franklin, ____________ discovered the structure of DNA.
A. 1915, Watson and Crick
B. 1953, Watson and Chargaff
C. 1953, Watson and Crick
D. 1951, Chargaff

Answers

Answer:

The answer is C.) 1953, Watson and Crick. In 1953, with the help of Rosalind Franklin, Watson and Crick discovered the structure of DNA.

Explanation:

To be specific, James Watson and Francis Crick were the first people to make a 3-D model of DNA. Although it may not seem much today, as our technology has advanced so much ever since, it was big time in 1953. They discovered that DNA was shaped like a double-helix, or twisting ladder. Pretty intriguing if you ask me!

he heme prosthetic group consists of protoporphyrin and an iron (II) ion. is the reason for cooperative binding of O2 by hemoglobin. is found only in myoglobin and hemoglobin. is the reason for cooperative binding of O2 by myoglobin.

Answers

Answer:

The correct answer is ''consists of protoporphyrin and an iron (II) ion.''

Explanation:

The heme group makes up the prosthetic (non-protein) group of hemoglobin and is responsible for its characteristic red color. It is composed of protoporphyrin IX, in the center of which is the ferrous ion (Fe+2). Protoporphyrin IX, in turn, is composed of four pyrrolic rings. The heme group is synthesized by the mitochondria, where protoporphyrin IX binds with the ferrous ion, before being released into the cytoplasm. The heme group is released in erythrocyte lysis, thus obtaining unconjugated or indirect bilirubin.

Lowest to highest degree of internal organization stomach

Answers

Answer: Epithelial stomach cell, stomach lining tissue, stomach and then the whole digestive system.

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TenishaTon Ambitious 5.1K answers 44.8M people helped

Which of the following processes releases heat?

Evaporation
Freezing
Melting
Sublimation

Answers

The correct answer is B: Melting

Answer:

Freezing

Explanation:

I got 123% on the quiz (Jokes aside yes it is freezing)

Unlike skeletal muscle, the muscle cells of the heart (called "cardiomyocytes") metabolize very little glucose, relying almost exclusively on metabolism of fatty acids for their energy. Which of the following statements are likely to be true of cardiomyocytes, but NOT skeletal myocytes? (select two answers)

a. low levels of glycogen storage, even when blood glucose is high
b. high levels of glycogen storage, even when blood glucose is low
c. low lactate production, even at high activity
d. high lactate production, even at low activity
e. many mitochondria compared to other cells
f. few mitochondria compared to other cells

Answers

Answer: A. low levels of glycogen storage, even when blood glucose is high.

C. low lactate production, even at high activity.

Explanation:

Cardiomyocytes are also known as the myocardiocytes. They are the cells which makes up make up the muscle if the heart. They're responsible for the generation of the contractile force in the heart which helps in the pumping if blood.

From the options given, the statements that are likely to be true of cardiomyocytes, but not of skeletal myocytes include:

• low levels of glycogen storage, even when blood glucose is high.

• low lactate production, even at high activity.

Answer:

The answer is A and C

Explanation:

Since cardiomyocytes are dependent on fatty acids, they rely on oxidative phosphorylation to generate energy, and consume very little glucose. Due to this, they have very low need for fermentation of pyruvate. In fact, they can absorb lactate generated by skeletal myocytes and erythrocytes and oxidize it for additional energy. Another consequence of this metabolism is that cardiomyocytes store little or no glucose as glycogen.

Skeletal myocytes and cardiomyocytes both have high energy needs and thus have more mitochondria than other cells. Cardiomyocytes have an even greater density of mitochondria than skeletal myocytes because they depend almost entirely on oxidative phosphorylation for their energy needs. This dependence on oxidative phosphorylation also explains the extraordinary sensitivity of cardiac muscle to hypoxic (low-oxygen) events. Without oxygen, cardiomyocytes rapidly run out of energy and can quickly die.

if you look away from this sentence and focus your eyes on a distant object, the eye muscles _______ to focus images on the retinas

Answers

If you look away from this sentence and focus your eyes on a distant object, the eye muscles relax to focus images on the retinas.

Traditionally, the classification of fungi has been based on the nature of sexual stages of the life cycle. For Penicillium, however, no sexual stages of the life cycle have been observed. Without evidence from sexual stages, speculate about other possible sources of evidence that scientists may use in classification.

Answers

Answer:

Without the evaluation of sexual stages, fungi can be classified according to the type of colony they present, the speed of growth, the formation of pigments and the type of coloration.

Explanation:

Although the observation of sexual stages is extremely efficient for the classification of fungi in the laboratory. This type of analysis is not always possible to be carried out. In that case, scientists need to find other methods that allow for the classification of fungi. These methods are carried out with the help of a microscope, where scientists observe the morphology of the fungi and are able to classify them according to the type of colony they present, the speed of growth, the formation of pigments and the type of coloration.

The difference between active transport and passive transport is that a. concentration gradients are involved in one and not in the other. b. glycolipids play a role in one and not in the other. c. one requires expenditure of energy by the cell and the other does not. d. ions are transported into and out of the cell by one process and not by the other.

Answers

Answer:

D) ions are transported into and out of the cell by one process and not by the other

Other Questions
1.) Create a single variable linear equation that has no solution. Solve the equation algebraically to prove that it does not have a solution.2.) Create a single variable linear equation that has one solution. Solve the equation algebraically to prove that there is one distinct solution for the equation.3.) Create a single variable linear equation that has infinitely many solutions. Solve the equation algebraically to prove that there is an infinite number of solutions for the equation Which of the following statements correctly explains the meaning of the term "95% confidence" in the confidence statement? The interval 52% to 58% is based on a procedure that includes a sample representing 95% of population. The interval 52% to 58% is based on a procedure that includes the true population value 95% of the time. The interval 52% to 58% is based on a procedure that produces a margin of error (of 3) 95% of the time. If a semi-circle was rotated about the y-axis, like the one shown below, what would be the resulting three-dimensional shape?PyramidCylinderSphere Cone Which of these is an example of an IT career? (ik I'm trash at this kinda stuff)Select all that applyAgame designerB network engineerC graphic designerD cashier 3.Question 3Adaptation does not occur for which of the following:1 pointa. grades b. noises c. moneyd. paralysis Trusts were least beneficial for which group?A. Factory WorkersB. BankersC. Small business ownersD. Large business owners A researcher is studying three wolf packs that hunt in the same area. The first pack preferentially kills mature, healthy moose; the second pack preferentially kills sick, old moose; and the third pack tends to kill an equal number of healthy and sick moose. Which pack likely plays the greatest role in determining the birth rate of the moose population help, please please help is this correct? Mr. L was walking through the woods wearing shorts and sandals. He noticed a small tick on his ankle the same evening, and several weeks later he developed flu-like symptoms. A sample of his blood revealed the presence of long, wavelike cells that were twisting and waving. Based on the microscopic findings, which type of microorganism is responsible for Mr. L's symptoms What are Rothenbergs major criticisms of students use of World Wide Web in writing research papers ? What is the correct order of structures in a chromosome from smallest to largest? nucleosome, nucleotide, histone, tight helical fiber, supercoil, chromosome nucleotide, histone, nucleosome, tight helical fiber, supercoil, chromosome nucleotide, nucleosome, histone, supercoil, tight helical fiber, chromosome nucleotide, histone, tight helical fiber, nucleosome, chromosome, supercoil Identify the members of the supply chain who are affected by a high forecast. (Check all that apply.) Multiple select question. The firms that own the supply chain incur the expenses of high forecasting. The operations managers pay for the costs incurred due to high forecasting. The workers pay for the costs incurred due to high forecasting. The customers pay for it in the form of higher prices. 8x square + 1 + 3square - 2 Explain the 11 sections that a typical bill of quantity is divided into In her classroom, Melissa regularly asks students to provide one compliment and one productive critique to one another's work. She also asks students to use the compliment/critique model to provide feedback on her teaching. In using these methods, Melissa is primarily demonstrating her skill as a: what is meant by psychological aspect of health,population and environment 3. How do you think Blakenships mining experiences compared to his experiences as a student?Document 1-Life for ChildrenI told my dad I wasnt going to school anymore. He said: Why, you just come on and go work with me. I went in the mines, and I went to work. From 31 to about the last of 32We lived eight miles from the mine, and we had to ride it horsebackMany times Id have to git off and hammer his feet out of the stirrups. Theyd be froze in the stirrupsWe got up at five in the mornin, start at six. We got out at ten that night. Wed work about six hours a day, seventeen hours.Buddy Blankenship, West Virginia miner Which entrepreneur matches each description? ILL GIVE BRAINLIST IF CORRECTLevi StraussMadame C.J. WalkerSteve JobsMary Kay Ashbuilt a successful beauty and cosmetics company and rewarded employees with pink CadillacsarrowRightbuilt a successful beauty and cosmetics company and donated money to scholarships for African American studentsarrowRightfounded a company that made sturdy denim blue jeans for gold minersarrowRightco-founded one of the world's most important tech companiesarrowRightReset Next Kayla parks her car at the corner of Ogilvie and Montreal Rd. She walks 80m East and then turns 30 to the left towards her office building and continues walking for another 100m until she reaches her building. She then takes the elevator to her office 60m above ground level and looks out the window. She can see her car from here. How far is it from where she is to her car in a direct line? As operations manager, you are concerned about being able to meet sales requirements in the coming months. You have just been given the following production report: JAN FEB MAR APR Units produced 2,250 1,750 2,750 2,950 Hours per machine 318 194 393 315 Number of machines 5 7 6 5 Find the average of the monthly productivity figures (units per machine hour).