In eukaryotes, miR-5 is a microRNA with sequence complementarity to the 3’UTR of the mRNA transcript encoded by the UCD gene. The UCD gene encodes for a protein that acts as an allosteric activator of the protein p101. The p101 protein is a DNA methyltransferase (DNMT) which is an enzyme that methylates DNA when the protein is in its active form.
A) In a lung cancer cell line, the p101 protein is overly active leading to misregulation of gene expression. In these lung cancer cells which of the following would be a correct prediction in regards to miR-5? [choose ALL that apply, note that incorrect selections will deduct points]
A) The gene encoding miR-5 is in a region of chromatin with hypoacetylation
B) The gene encoding miR-5 is in a region of chromatin with hyperacetylation
C) The gene encoding miR-5 in a region of euchromatin
D) The gene encoding miR-5 in a region of heterochromatin
E) The miR-5 transcript is translated at high levels
F) The miR-5 transcript is activating translation of the UCD gene
B) A different lung cancer cell line is found to have significantly decreased amounts of DNA methylation. Which of the following could explain why there is decreased DNA methylation in this cell line? [choose ALL that apply, note that incorrect selections will deduct points]
A) increased amounts of the p101 protein due to low levels of miR-5
B) increased amounts of the UCD protein due to high levels of miR-5
C) decreased amounts of the UCD protein due to low levels of miR-5
D) the absence of the UCD protein due to miR-5 inhibiting translation of the UCD mRNA transcript
E) the absence of the p101 protein due to miR-5 inhibiting transcription of the p101 mRNA transcript

Answers

Answer 1

Answer:

A) A) The gene encoding miR-5 is in a region of chromatin with hypoacetylation.  

D) The gene encoding miR-5 in a region of heterochromatin.

B) D) the absence of the UCD protein due to miR-5 inhibiting translation of the UCD mRNA transcript

Explanation:

MicroRNAs (miRNAs) are small regulatory RNA sequences (approximately 20-24 nucleotides in length) that regulate gene expression by RNA interference (RNAi) mechanisms. These sequences (miRNAs) bind by base complementarity to messenger RNAs and thus inhibit protein translation and/or trigger mRNA degradation. In this case, miR-5 binds to the 3’UTR of the mRNA transcript of the UCD gene, thereby inhibiting/slowing protein UCD synthesis. The UCD protein is an allosteric regulator that binds and activates the expression of the p101 protein, thereby the miR-5 RNAi pathway also indirectly decreases the expression of the p101 gene. Moreover, hypoacetylation is an epigenetic mark generally associated with gene silencing (heterochromatin is a transcriptionally inactive state of chromatin).


Related Questions

Unlike skeletal muscle, the muscle cells of the heart (called "cardiomyocytes") metabolize very little glucose, relying almost exclusively on metabolism of fatty acids for their energy. Which of the following statements are likely to be true of cardiomyocytes, but NOT skeletal myocytes? (select two answers)

a. low levels of glycogen storage, even when blood glucose is high
b. high levels of glycogen storage, even when blood glucose is low
c. low lactate production, even at high activity
d. high lactate production, even at low activity
e. many mitochondria compared to other cells
f. few mitochondria compared to other cells

Answers

Answer: A. low levels of glycogen storage, even when blood glucose is high.

C. low lactate production, even at high activity.

Explanation:

Cardiomyocytes are also known as the myocardiocytes. They are the cells which makes up make up the muscle if the heart. They're responsible for the generation of the contractile force in the heart which helps in the pumping if blood.

From the options given, the statements that are likely to be true of cardiomyocytes, but not of skeletal myocytes include:

• low levels of glycogen storage, even when blood glucose is high.

• low lactate production, even at high activity.

Answer:

The answer is A and C

Explanation:

Since cardiomyocytes are dependent on fatty acids, they rely on oxidative phosphorylation to generate energy, and consume very little glucose. Due to this, they have very low need for fermentation of pyruvate. In fact, they can absorb lactate generated by skeletal myocytes and erythrocytes and oxidize it for additional energy. Another consequence of this metabolism is that cardiomyocytes store little or no glucose as glycogen.

Skeletal myocytes and cardiomyocytes both have high energy needs and thus have more mitochondria than other cells. Cardiomyocytes have an even greater density of mitochondria than skeletal myocytes because they depend almost entirely on oxidative phosphorylation for their energy needs. This dependence on oxidative phosphorylation also explains the extraordinary sensitivity of cardiac muscle to hypoxic (low-oxygen) events. Without oxygen, cardiomyocytes rapidly run out of energy and can quickly die.

why do sun spots appear darker than their surroundings

Answers

Answer:

they are comer than their surroundings.

Sunspots are cooler because their magnetic fields inhibit the replenishing of heat from convective flows (due to the interaction between plasma and magnetic fields). This allows them to cool radiatively. The rest of the solar surface is constantly being replenished by convective cells that reheat it.

Answer:

because they are significantly cooler than the rest of the Sun's surface Despite their gloomy appearance, they are nonetheless extremely hot. A sunspot would shine brightly if it were alone in space.

OAmalOHopeO

what are the points included in women's rights ​

Answers

Answer:

Explanation:These later evolved into six general points of equality for women: political, occupational, moral, social, economic and legal.

What is the responsibility of a scientist

Answers

Answer:

A scientist is in charge of societal concerns as well as the practical application of his innovation. He must abide by intellectual property rights so that his new innovation is open and honest. Ethics is the bedrock of any study.

OAmalOHopeO

4.In humans, the allele which confers the ability to roll the tongue is dominant over the allele which does not confer the ability to roll the tongue. If a man who can roll his tongue and whose mother could not mates with a woman who cannot roll her tongue, what proportion of the children would be expected to be able to roll their tongues if they have a large number of children

Answers

Answer:

The correct answer is - 1/2

Explanation:

the ability to roll the tongue is dominant over those who can not roll the tongue. The man is Rr (man), heterozygous. The woman is recessive and can not roll

Rr (man) x rr (woman)---Parents

           r

R Rr (roll)

r rr (cann't roll)

The probability of their children to able to roll = 1/2 = 50%

Question 4 of 10
Erin is studying the rate at which bananas turn brown as part of her science
fair project. Her teacher asked her to include a scientific question in the
presentation. Which of the following is a reasonable scientific question for
Erin's project?
A. Do bananas prefer the temperature inside the refrigerator or on the
countertop?
B. Should students be required to do science fair projects?
C. What hypothesis is likely to lead to a winning science fair project?
D. How does the air temperature affect the rate at which a banana
turns brown?

Answers

Answer:

D. How does the air temperature affect the rate at which a banana

turns brown?

b. Bobcats are another predator of snowshoe hare. If a population of bobcats immigrates to the
area, how is this likely to affect the habitat's carrying capacities for hare and lynx?

Answers

Answer:

Decrease population and carrying capacity.

Explanation:

If a population of bobcats immigrates to the  area, the population of hare and lynx decreases that also affect the habitat's carrying capacities for hare and lynx because bobcats feed on both hare and lynx. Bobcats are very aggressive in nature, and has an aggressive hunting style. With these characteristics, the bobcats can hunt both hare and lynx which leads to decrease in population and carrying capacity.

Which structure transports urine to the bladder by peristaltic action?

Answers

Answer:

The muscular layer of the ureter consists of longitudinal and circular smooth muscles that create the peristaltic contractions to move the urine into the bladder without the aid of gravity.

Answer:

The ureter

Explanation:

The ureter is a long thin tubular structure 10-12 inches long which carries urine produced in the kidney to the bladder. The urine is transported by a process called peristalsis. The ureter actively propels urine from the kidney down into the bladder.

plz give a correct answer for the question how do canine and molar differ​

Answers

Answer:

Canines are the sharp, pointed teeth that sit next to the incisors and look like fangs. Dentists also call them cuspids or eyeteeth. Canines are the longest of all the teeth, and people use them to tear food

Molars are the flat teeth at the rear of the mouth. Each molar typically has four or five cusps. They are used exclusively for crushing and grinding. Wisdom teeth are also called third molars. They erupt from the age of 18 onwards but are often surgically removed.Their function is similar to that of the premolars, to grind, tear, and crush food. Molars have a large flat biting surface which makes them perfect for this job.

Explanation:

Hope it works!!!!

Canine are used to tear and found in front of mortal
Mortal are used to chew

what are the effects of under secretion of steroid hormones​

Answers

Answer:

Anabolic steroids are related to testosterone, the major male hormone. Abusing the hormone can lead to physical and psychological side effects. Problems include breast development and hair loss among men, and facial hair growth, menstrual problems, and a deepened voice in women.

The process by which dissolved gases are exchanged between the blood and interstitial fluids is Select one: a. cellular respiration. b. diffusion. c. external respiration. d. breathing. e. pulmonary ventilation.

Answers

Answer:

b. diffusion.

Explanation:

Diffusion can be defined as the movement of gas molecules from a region of high concentration to a region of lower concentration until an equilibrium is attained or reached. This mixing of gas molecules in the liquid or gaseous state is due to their kinetic energy of random motion i.e without requiring bulk motion.

This ultimately implies that, diffusion is a phenomenon through which gas molecules in either a gaseous or liquid state spread out in response to a concentration gradient, which is simply the difference in concentration of the gases across a space.

During diffusion, molecules move from areas of high concentration to areas of low concentration.

In this context, the process by which dissolved gases are exchanged between the blood and interstitial fluids is referred to as diffusion.

On a related note, this process is also referred to as internal respiration because it involves the exchange of oxygen gas and carbon (II) oxide gas between tissue cell and capillaries.

what is the Biology?​

Answers

Answer:

This is the study of life

the study of living organisms, divided into many specialized fields that cover their morphology, physiology, anatomy, behavior, origin, and distribution.

GOLGI APPARATUS IS THE IMPORTANT SITE OF FORMATION OF____________& ______________​

Answers

Glycoproteins and Glycolipids.

GOLGI APPARATUS IS THE IMPORTANT SITE OF FORMATION OF GLYCOPROTEINS & GLYCOLIPIDS.

Traditionally, the classification of fungi has been based on the nature of sexual stages of the life cycle. For Penicillium, however, no sexual stages of the life cycle have been observed. Without evidence from sexual stages, speculate about other possible sources of evidence that scientists may use in classification.

Answers

Answer:

Without the evaluation of sexual stages, fungi can be classified according to the type of colony they present, the speed of growth, the formation of pigments and the type of coloration.

Explanation:

Although the observation of sexual stages is extremely efficient for the classification of fungi in the laboratory. This type of analysis is not always possible to be carried out. In that case, scientists need to find other methods that allow for the classification of fungi. These methods are carried out with the help of a microscope, where scientists observe the morphology of the fungi and are able to classify them according to the type of colony they present, the speed of growth, the formation of pigments and the type of coloration.

Nguyên nhân gây bệnh quáng gà ở người là do:đâu

Answers

Answer:

nearsightedness, or blurred vision when looking at faraway objects cataracts, or clouding of the eye's lens retinitis pigmentosa

Explanation:

If a small drop of tiny particles such as pollen grains are dropped into a drop of water on a microscope slide, they will appear to vibrate and spread out. The primary reason for this is a. Currents in the water are pushing them around. b. They have internal energy and that is causing them to move. c. They are being continually struck by randomly moving water molecules from all sides and those strikes fluctuate and are sometimes uneven. d. Internal forces between the particles cause them to repel and attract.

Answers

Answer:

Internal forces between the particles cause them to repel and attract.

If the average length of a woman's ovarian cycle is 30 days, the average length of her uterine cycles is most likely ____ days.

a. 7
b. 30
c. 21
d. 15
e. 10

Answers

It most likely 30 days
Most likely 21 to 35 days, so I would choose 21 here.

New world monkeys have:______.
a. None of the above
b. have short legs and no tails to help them balance on top of the branches where they walk
c. have prehensile tails to aid in their 3-D movement through the trees
d. have broad and flat bodies with the scapula on the back of the ribcage, allowing a greater range of motion in the shoulder and for them to hold their arms above their heads.

Answers

Answer:

d num have broad and flat bodies

Answer:

C. have prehensile tails to aid in their 3-D movement through the trees

Explanation:Monkeys need tails to balance themselves when walking and jumping from tree to tree

g In order to stimulate the renin-angtiotensin-aldosterone system (RAAS), _______________ cells in the kidney detect _______________blood pressure which causes ________________ to be released from the juxtaglomerular cells.

Answers

Answer:

Macula densa cells, lower and renin.

Explanation:

Macula densa cells in the kidney detect lowers blood pressure which causes renin to be released from the juxtaglomerular cells which is  an enzyme. The arterial cells observe the drop in blood pressure, and the decrease in Na concentration is transfer to them by the macula densa cells. The juxtaglomerular cells then release an enzyme called renin. Renin converts angiotensinogen which is a peptide, or amino acid derivative into angiotensin-1.

Describe the composition and structure of DNA. Include the parts of the DNA molecule, and how it is put together, including the types of bonds.

Answers

DNA is a double helix composed of nitrogenous bases, which form hydrogen bonds with each other. It also contains a deoxyribose sugar and phosphate backbone.

If you were to record the activity of a mirror neuron, you should expect that it would act in the same way
when we perform an action - such as picking up an object - as when we:
A. choose to not perform that action
B. observe someone else perform that action
C. read about performing that action
D. think about performing that action

Answers

Answer:

f

Explanation:

The difference between active transport and passive transport is that a. concentration gradients are involved in one and not in the other. b. glycolipids play a role in one and not in the other. c. one requires expenditure of energy by the cell and the other does not. d. ions are transported into and out of the cell by one process and not by the other.

Answers

Answer:

D) ions are transported into and out of the cell by one process and not by the other

Carnivore that feeds on primary consumers
Question 3 Multiple Choice Worth 3 points
(01.01 LC)
Which of the following is an example of a decomposer?

Answers

we need the options in order to answer

In the cell bio lab, we use company manufactured gels, however you can make you own polyacrylamide gels. List all of the ingredients found in an SDS-PAGE gel. Which ingredients are responsible for polymerizing the solution?

Answers

Answer:

The list of ingredients are used in this method are as follow-

1. Acrylamide - mostly 30%

2. Bisacrylamide - mostly 0.8%

3. 1.5M Tris-Hcl pH 6.8 for stacking gel and 8.8 for separating gel.

4. 10% SDS

5. 10% APS

6. TEMED

7. Double distilled water

Polymerization:

Acrylamide is a polymer that is used to dissolved in buffer and bisacrylamide is the cross linking agen.

Two types of gels are prepared for separation of protein. Stacking gel is usually 4 or 6% and separating gel is usually 10 to 20%. Lower concentration of stacking gel will allow the migration of all the protein same because of larger pore size. It will stack or line up the proteins for its next level of separation.

Higher concentration of separating gel will provide resistance to the movement of protein because of the low pore size and therefore linear bands can be achieved neatly.

(URGENT!!!) (BRAINLIEST!!!)
The diagram below shows four layers of Earth.


Which of these layers of Earth contains mainly solid iron? (100 points)


Layer A

Layer B

Layer C

Layer D

Answers

Answer:

Layer A

Explanation:

The innermost layer that is present at the center of the earth is mainly made up of solid iron. So option A is correct.

The innermost layer of the Earth is the innermost core. The innermost core is a solid metal ball composed mostly of iron. Inside the innermost core, temperatures are extremely high, with an estimated inner core temperature of 7200–8 500ºF (4000–4 700ºC). The innermost core of the Earth is not molten like the outermost core.

The solid inner core lies 3,200 kilometers below the Earth’s crust and is separated from the semi-solid mantle by a liquid outer core.

To learn more about iron, refer to the link:

https://brainly.com/question/31984794

#SPJ2

characteristics of invertebrates​

Answers

Answer:

they don't have back bone.

What allows humans to have different traits from each other?
A. They store DNA in different places.
B. They have different genes.
C. They have different haploidnumbers.
gling
D. They have different number
Ichromosomes.
SUBMIT

Answers

Answer:

B. They have different genes.

Explanation:

Which diagram best explains changes to the composition of blood in the lungs?
Кеу
to,
fco
(A)
(B)
Alveolus
Blood
Alveolus
Blood
Capillary
Capillary
(C)
(D)
Alveolus
Blood
Alveolus
Blood
Capillary
Capillary​

Answers

Answer:

A

Explanation:

Just because

By the early 1980s, the population of Florida panthers had dwindled to fewer than 30. Furthermore, within this population was a high frequency of detrimental traits, including low sperm count and undescended testicles in males, and kinked tails in both sexes. The future for this iconic population was bleak at best. Provide an explanation for the observed detrimental traits. Provide a possible solution that would both increase the likelihood that the population would survive and preserve the genetic identity of this unique population.

Answers

Answer:

The population suffered a genetic bottleneck, which decreased genetic variation and thereby randomly increasing the frequency of harmful alleles

Explanation:

A population bottleneck, also known as genetic bottleneck, can be defined as a drastic reduction in the size of a population, which may be caused by anthropic activity and/or environmental phenomena (e.g., earthquakes, famines, fires, droughts, etc). A genetic bottleneck leads to a reduction in genetic variability within a population. Moreover, the genetic drifit caused by a genetic bottleneck can also increase the frequency of harmful alleles/mutations (it is due to the random sampling of individuals), thereby increasing the frequency of deleterious alleles/mutations in the population.

A woman who is a carrier for #1 hemophilia and a man that does not have the
condition have children. What is the probability that they will have a child
with the condition being studied? What is the gender of that child?


#2 In plants, inflated pea pods are dominant to constricted pea pods. Two pea pods both heterozygous for pod shape are crossed. What is the probability that they could produce constricted pea pods ?


#3 A woman that is heterozygous for Huntington's disease and a man that does not have the condition have children . What is the probability that their children inherit the Huntington's gene ?

#4 A woman that is heterozygous for type A blood and a man that is heterozygous for type B blood have children. What are the possible blood types of their children?

#5 Two people are both unknowingly carriers for the cystic fibrosis gene. What is the probability that they will have children with cystic fibrosis?

Answers

Answer:

Explanation:

A woman who is a carrier for #1 hemophilia and a man that does not have the condition have children. What is the probability that they will have a child with the condition being studied? What is the gender of that child?

if the baby gets the Y chromosome from the father it will be a boy. If the boy gets his mother's X chromosome with the hemophilia gene he will have hemophilia. If he inherits his mother's other X chromosome, he will have normal blood clotting. If the baby gets the X chromosome from the father it will be a girl.

#4 A woman that is heterozygous for type A blood and a man that is heterozygous for type B blood have children. What are the possible blood types of their children?

One parent with A and another with B can produce a child with A, B, AB or O blood types.

#5 Two people are both unknowingly carriers for the cystic fibrosis gene. What is the probability that they will have children with cystic fibrosis?

If both parents are carriers there is a 1 in 4 (25 percent) chance that both will pass on the non-functioning gene, which would result in a pregnancy affected with cystic fibrosis.

#3 A woman that is heterozygous for Huntington's disease and a man that does not have the condition have children . What is the probability that their children inherit the Huntington's gene ?

Huntington's disease (HD) is what is called a dominant genetic disease. What this usually means is that a child only has a chance of getting a disease like this if a parent has it too. But parents without HD can have a child with HD. This is true of any dominant genetic disease

Other Questions
A certain university has 25,000 registered students. To estimate the percentage who are living at home, a simple random sample of 400 students is drawn. It turns out that 317 of them are living at home. Now, 317 out of 400 is (about) 79%. Indicate whether each quantity is actual or estimated from the data. You'll get partial credit for What is the formula for manganese (IV) oxide?A. MnO4B. Mn40C. MNO2D. 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Write a Python program that makes a turtle draw the shape below, which consists of 8 squares in a row: Express -5/8 as a rational number with -24 as the denominator The length of the hypotenuse is?? Flagstaff Company has budgeted production units of 9,800 for July and 10,000 for August. The direct labor requirement per unit is 0.40 hours. Labor is paid at the rate of $20 per hour. The total cost of direct labor budgeted for the month of August is: Multiple Choice $78,400. $4,000. $80,000. $3,920. $158,400. Read the following excerpt from a biography on Mark Twain and answer the question.Samuel Langhorn Clemens, Mark Twain, was born in Florida, Missouri on November 30,1835. The experience of his life prepared him as a writer, an American writer. He worked as a printer, then apprenticed himself as a river pilot on the Mississippi, and eventually became one of the best. He worked at mining activities in Nevada. In 1862, he took a position on the Virginia City Enterprise where he first used the name Mark Twain, which was a riverboat pilot expression.He went to the West Coast and worked for a while on the San Francisco newspaper, Morning Call. After leaving there, he went to Calaveras County to try his hand at mining. In 1865, he was asked by Artemus Ward to write a humorous sketch. He signed it "Mark Twain," and his reputation began on the eastern seaboard. In 1866, he was sent by the Sacramento Union to Hawaii. Unexpectedly, in 1867, he sailed abroad and wrote letters that were to become the book, The Innocents Abroad. With that book he became the most famous humorist of his time. In July, 1869, The Innocents Abroad was published. 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